• Document: Optotune. Microscopy. Zurich, July Dr. David Leuenberger, Business Development Manager
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Optotune Microscopy Zurich, July 2017 Dr. David Leuenberger, Business Development Manager Bernstrasse 388 | CH-8953 Dietikon | Switzerland Phone +41 58 856 3011 | www.optotune.com | info@optotune.com Agenda • Company presentation • Why tunable lenses for microscopy? • Tunable lens technology • Integration of tunable lenses • Application examples • Conclusion 2 Optotune on a page Founded 2008 Leader in tunable optics 25 sales partners in 30 countries 70 employees HQ located in Zurich, Switzerland Privately owned 3 Optotune provides three core product lines Focus tunable lenses Laser speckle reducers Beam steering devices 4 Expansion of product portfolio over the years 5 Our vision: Enable optical innovations Enables product By delivering key Based on platform innovation components technologies • Compact & fast autofocus • Tunable lenses • Membranes & liquids • 3D laser processing • Laser speckle reducers • Electroactive polymers • Laser-based cinema • Beam steering devices • Reluctance force actuators 6 Expertise in house from R&D to production 7 Optotune’s market focus Laser projection Machine vision Laser processing  High-resolution, speckle-free  Focus within milliseconds  Fast control of Z-axis projections  Working distances from infinity  Compact, reliable design with  Ultra-compact solution with no to 50mm less mechanics mechanics  Maximal flexibility  Easy to integrate  Low power consumption Medical Microscopy Custom design  Compensation of visual defects  Axial focusing over several  What is your application?  Continuous adjustment in real- 100um within milliseconds time  Backward compatibility with  +/- 20 diopters spherical, several types of microscopes +/- 10 diopters cylindrical  Speckle-free laser illumination 8 Agenda • Company presentation • Why tunable lenses for microscopy? • Tunable lens technology • Integration of tunable lenses • Application examples • Conclusion 9 Starting point Today, most microscopes take 2D images, but … …Life is 3-dimensional !! 10 Starting point Modern biology wants • Imaging of 3D cell cultures • Imaging of whole embryos • In-vivo imaging in living animals Issue: • Microscopes have a limited “depth of field” (DOF) • The higher the lateral resolution, the smaller the DOF Solution: • 3D microscope 11 3D microscopy techniques Wide-field microscopy Confocal microscopy Two-photon microscopy Light-sheet microscopy 3 Need to scan along z-axis Solutions:  Motorized stages Slow bulky  Piezo-stages small travel expensive  Focus tunable lenses Fast Compact accurate 13 USP for 3D microscopy • Fast (> 100 Hz), compact and accurate 3D scanning • >100x Faster than motorized solutions • >3x cheaper than piezo stages • Larger z-range than with piezo stages (up to 600 µm with 40x objective) 14 Agenda • Company presentation • Why tunable lenses for microscopy? • Tunable lens technology • Integration of tunable lenses • Application examples • Conclusion 15 How does it work? Membrane Lens shaper Fluid Videos available on www.optotune.com 16 The focal power (D = 1/f ) of Optotune’s lenses is controlled by current MV LP Note: This curve varies from lens to lens. However, it is reproducible once calibrated 17 Focus tunable polymer lenses for multi-spectral applications Lens schematic 100 90 80 70 Transmission [%] 60 50 40 30 20 Lenses with LD material 10

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