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Xcellerex™ XDR-50 to 2000 Bioreactor Systems Operating Instructions Original instructions Table of Contents Table of Contents 1 Introduction .......................................................................................................... 7 1.1 About this manual ................................................................................................................................ 8 1.2 Important user information ............................................................................................................. 9 1.3 Regulatory information ...................................................................................................................... 12 1.4 Abbreviations .......................................................................................................................................... 14 2 Safety instructions ............................................................................................... 15 2.1 Safety precautions ............................................................................................................................... 16 2.2 Labels ......................................................................................................................................................... 30 2.3 Center of gravity ................................................................................................................................... 37 2.4 Emergency procedures ...................................................................................................................... 38 2.5 Interlocks .................................................................................................................................................. 44 2.6 Security levels ......................................................................................................................................... 45 2.7 Recycling information ......................................................................................................................... 49 2.8 Declaration of Hazardous Substances (DoHS) ........................................................................ 51 3 System description .............................................................................................. 54 3.1 Safety system ......................................................................................................................................... 56 3.2 System overview ................................................................................................................................... 58 3.3 XDR vessel ................................................................................................................................................ 60 3.4 I/O Cabinet ............................................................................................................................................... 65 3.5 X-Station ................................................................................................................................................... 69 3.6 Disposable bag assembly ................................................................................................................. 71 3.7 Probe sheath assembly ..................................................................................................................... 75 3.8 Agitator ...................................................................................................................................................... 77 3.9 Agitator motor lifting system .......................................................................................................... 80 3.10 Load cells .................................................................................................................................................. 83 3.11 Exhaust filter heater assembly ....................................................................................................... 86 3.12 Pumps ........................................................................................................................................................ 89 3.13 Bag hoist .........................................................................................................